Author

V. Vinod Mootha

The University of Texas Southwestern Medical CenterORCID 0000-0003-4861-7221Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

David R. CoreyiD· 2 shared Jiaxin HuiD· 2 shared Xin GongiD· 2 shared C. Bradley Bowman· 1 shared Chao XingiD· 1 shared Dhrubajyoti DattaiD· 1 shared Hanquan Liang· 1 shared Jayanta KunduiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

David R. CoreyORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMar 11, 2025

Modulation of TTR Gene Expression in the Eye using Modified Duplex RNAs

Jiaxin Hu, Xin Gong, Jayanta Kundu…·David R. Corey

This study shows lipid-modified siRNAs can inhibit TTR gene expression in the eye via intravitreal injection, suggesting a potential therapy for ocular TTR amyloidosis.

DOI 10.1101/2025.03.11.642595

humanbulk RNA-seq

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Molecular BiologyNucleic Acids ResearchPeer-reviewedMay 11, 2020

Analyzing Presymptomatic Tissue to Gain Insights into the Molecular and Mechanistic Origins of Late-Onset Degenerative Trinucleotide Repeat Disease

Yongjun Chu, Jiaxin Hu, Hanquan Liang…·V. Vinod Mootha

The paper uses RNAseq to compare presymptomatic and late-stage FECD tissue, finding early splicing and gene expression changes that predict fibrosis and immune activation in late-stage disease.

51 citations

humanbulk RNA-seq

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