Xin Gong

This study identifies a plant-specific CHD3 chromatin remodeling complex involving J-proteins that maintains H3K27me3 spreading and cell identity by stabilizing PKL and enhancing its remodeling activity.

This study shows lipid-modified siRNAs can inhibit TTR gene expression in the eye via intravitreal injection, suggesting a potential therapy for ocular TTR amyloidosis.

The paper uses RNAseq to compare presymptomatic and late-stage FECD tissue, finding early splicing and gene expression changes that predict fibrosis and immune activation in late-stage disease.