Multi-region biopsies and patient-derived neurosphere cultures reveal spatial divergence in glioblastoma.
Roberto Salatino, Jacob Geisberg, Arantxa Romero-Toledo…·Michalina Janiszewska
This study shows that multi-region neurospheres from glioblastoma tumors retain spatial diversity and drug response patterns linked to their original biopsies, highlighting their importance for modeling intratumor heterogeneity.