Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations
Bernard K. van der Veer, Lehua Chen, Spyridon Champeris Tsaniras, Wannes Brangers, Qiuying Chen, Mariana Schroiff, Colin Custers, Harm H.M. Kwak, Rita Khoueiry, Robert M. Cabrera, Steven S. Gross, Richard H. Finnell, Yunping Lei, Kian Peng Koh
This study identifies TET1 as a key mediator of gene-environment interactions in congenital malformations, showing how maternal folate status and genetic background influence DNA methylation and NTD susceptibility.
bioRxiv · Feb 21, 2024 · PreprintDevelopmental Biology