Kian Peng Koh

This study shows maternal vitamin C deficiency in mice leads to DNA hypermethylation and congenital defects, suggesting VitC supplementation may prevent birth defects.

This study identifies TET1 as a key mediator of gene-environment interactions in congenital malformations, showing how maternal folate status and genetic background influence DNA methylation and NTD susceptibility.

This study shows that hyperosmolar conditions induce cell cycle exit and differentiation in pluripotent cells through NF-κB and WNT signaling pathways.

This study shows that Wnt/TCF7L1 repression promotes primitive endoderm differentiation in mESCs by inhibiting naive and formative pluripotency factors.

This study identifies sequential activation of Tet1 and Oct4 during iPSC reprogramming, revealing distinct DNA demethylation waves and epigenetic dynamics critical for generating high-quality iPSCs.