Bernard K. van der Veer

Mitigating genotype-driven bias improves atlas-scale single-cell DNA methylome profiling

The paper mitigates genotype-driven bias in single-cell DNA methylation analysis by masking variant positions, improving clustering and reducing spurious methylation differences in pooled datasets.

Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation.

This study shows maternal vitamin C deficiency in mice leads to DNA hypermethylation and congenital defects, suggesting VitC supplementation may prevent birth defects.

Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations

This study identifies TET1 as a key mediator of gene-environment interactions in congenital malformations, showing how maternal folate status and genetic background influence DNA methylation and NTD susceptibility.

Osmolar modulation drives reversible cell cycle exit and human pluripotent cell differentiation via NF-κB and WNT signaling

This study shows that hyperosmolar conditions induce cell cycle exit and differentiation in pluripotent cells through NF-κB and WNT signaling pathways.

The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency

This study shows that Wnt/TCF7L1 repression promotes primitive endoderm differentiation in mESCs by inhibiting naive and formative pluripotency factors.