This study shows magnesium and folate reduce dolutegravir toxicity in zebrafish embryos, with magnesium acting through both folate receptor-dependent and -independent mechanisms.

Disease Models & Mechanisms · Apr 23, 2026Peer-reviewedDevelopmental Biology

Decoding the RNA Splicing Network in HNRNPH2-R114W Brain Organoids

Carlo Donato Caiaffa, Neda Ghousifam, Stephen Watkins, Helder Imoto Nakaya, Rodney A. Bowling, Richard H. Finnell, Robert M. Cabrera

This study investigates the impact of the HNRNPH2-R114W mutation on RNA splicing in human brain organoids, identifying junction-level dysregulation and potential therapeutic targets.

bioRxiv · Feb 9, 2026 · PreprintNeuroscience

Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations

Bernard K. van der Veer, Lehua Chen, Spyridon Champeris Tsaniras, Wannes Brangers, Qiuying Chen, Mariana Schroiff, Colin Custers, Harm H.M. Kwak, Rita Khoueiry, Robert M. Cabrera, Steven S. Gross, Richard H. Finnell, Yunping Lei, Kian Peng Koh

This study identifies TET1 as a key mediator of gene-environment interactions in congenital malformations, showing how maternal folate status and genetic background influence DNA methylation and NTD susceptibility.

bioRxiv · Feb 21, 2024 · PreprintDevelopmental Biology