Filament formation is a conserved mechanism of Thoeris SIR2 effector activation
Biswa P. Mishra, Veronika Masic, Tamim Mosaiab, Harshika Belani, Trent Conroy, Lou Brillault, Crystall M. D. Swarbrick, Zhiyu Zang, Boštjan Kobe, Yun Shi, Mark von Itzstein, Joseph P. Gerdt, Thomas Ve
This study shows that 3'cADPR-induced SIR2 filament formation activates ThsA effectors in type I Thoeris systems across bacterial species.
bioRxiv · Mar 2, 2026 · PreprintMicrobiology