BiochemistrybioRxivPreprint
Chemical inactivation of a bacterial immune system de-domesticates a temperate phage and promotes its spread
Yanyao Cai, J. LAZAR, Yun Shi…·Joseph P. Gerdt
The paper identifies chemical inhibitors of SpbK, an antiphage defense system in Bacillus subtilis, showing they promote phage dissemination and reveal mechanisms of inhibiting TIR-domain enzymes.
DOI 10.64898/2026.05.14.725270