Systematic characterization of cancer-associated SPOP mutants reveals novel and reprogrammable degradative activities
Alana G. Caldwell, Harshil Parmar, Xiaokang Jin, Chen Zhou, Xiaoyu Zhang
This study characterizes cancer-associated SPOP mutants, showing their degradative activities and potential for therapeutic repurposing.
ChemBioChem · Jan 1, 2026Peer-reviewedBiochemistry