CK2 variant function and disease modelling in Drosophila reveal allelic heterogeneity and Wnt/β-catenin-mediated phenotypes
Yina Her, Danielle M. Pascual, Ying Lao, Harsimran Kaur, Alondra Griffiths, Robert Beattie, Bradley W. Doble, Patrick Frosk, René Peiman Zahedi, Paul C. Marcogliese
The paper uses Drosophila to model CK2 variants causing neurodevelopmental disorders, finding loss- and gain-of-function effects and Wnt/β-catenin-mediated phenotypes.
bioRxiv · Aug 21, 2026 · PreprintGenetics