Wado Akamatsu

This study uses human iPSC-derived brain-intestinal assembloids to show synuclein propagation from brainstem to enteric neurons and identifies NRXN1-NLGN2 signaling as a key mediator.

The paper shows that PSEN1 variants in early-onset Alzheimer's disease cause abnormal Ca2+ bursts in neurons via RyR2, which can be suppressed by carvedilol.

This study examines electrophysiological differences in iPSC-derived neurons from sleep bruxism patients with a HTR2A variant, finding altered action potential properties compared to controls.