Targeting C5aR1 Reveals Protective Macrophage Maturation States in Intestinal Injury
Heather Clark, Ian J. Chai, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Yanyan Jiang, Kerriann M. Casey, Iryna Zherka, Dominika Majorova, Trent M. Woodruff, Edward Elliot Graves, Quynh‐Thu Le, Simon J. A. Buczacki, Amato J. Giaccia, Monica M. Olcina
This study shows targeting C5aR1 reduces radiation-induced intestinal injury by promoting macrophage phenotypes that decrease stem cell apoptosis and improve tumor response.
bioRxiv · Nov 11, 2025 · PreprintImmunology