Author

Ian J. Chai

University of OxfordORCID 0009-0008-0617-1114Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Monica M. OlcinaiD· 2 shared Amato J. GiacciaiD· 1 shared David MacLeaniD· 1 shared Dhanya K. NambiariD· 1 shared Dominika Majorova· 1 shared Edward Elliot GravesiD· 1 shared Ester M. HammondiD· 1 shared Geoff Stuart HigginsiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Monica M. OlcinaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 11, 2025

Targeting C5aR1 Reveals Protective Macrophage Maturation States in Intestinal Injury

Heather Clark, Ian J. Chai, Stavros Melemenidis…·Monica M. Olcina

This study shows targeting C5aR1 reduces radiation-induced intestinal injury by promoting macrophage phenotypes that decrease stem cell apoptosis and improve tumor response.

DOI 10.1101/2025.11.11.687632

mouseexperimental assay

𝕏 PostBluesky

Cancer BiologyCell Death and DiseasePeer-reviewedJul 22, 2025

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment by regulating tumour cell fate

Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai…·Monica M. Olcina

This study shows hypoxia induces intracellular C5aR1 via UPR, promoting tumour cell survival by regulating autophagy and apoptosis.

6 citations

humanexperimental assay

𝕏 PostBluesky