Huntingtin lowering reduces somatic instability at CAG-expanded loci
Sydney R. Coffey, Marissa A Andrew, Heather Ging, Joseph Hamilton, Michael D. Flower, Marina V. Kovalenko, Robert M. Bragg, Jeffrey P. Cantle, Cassandra A. McHugh, José M. Carrillo, Julie-Anne Rodier, Deanna M. Marchionini, Hilary A. Wilkinson, Seung Kwak, David Howland, , Jeffrey B. Carroll
This study shows that reducing huntingtin protein levels decreases somatic instability in CAG-expanded loci in both mouse models and human neurons.
bioRxiv · Jul 23, 2020 · PreprintNeuroscience