Author

Hilary A. Wilkinson

CHDI FoundationORCID 0000-0002-0401-9329Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Frank BennettiD· 2 shared Cassandra A. McHughiD· 2 shared David HowlandiD· 2 shared Deanna M. MarchioniniiD· 2 shared Holly B. KordasiewicziD· 2 shared Jeffrey B. CarrolliD· 2 shared Jeffrey P. CantleiD· 2 shared Marina V. KovalenkoiD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

C. Frank BennettORCID

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2 papers

Recent·Most cited

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding

Ella W. Mathews, Sydney R. Coffey, Annette Gärtner, Jillian Belgrad, Robert M. Bragg, Daniel O’Reilly, Jeffrey P. Cantle, Cassandra A. McHugh, Ashley Summers, Joachim Fentz, Tom Schwagarus, Antje Cornelius, Ioannis Lingos, Zoe N. Burch, Marina V. Kovalenko, , Jeffrey B. Carroll

This study investigates how different HTT-lowering therapies affect somatic instability in HD mice, finding that transcriptional repression and CAG repeat binding reduce SI without lowering HTT levels.

Nature Communications · Nov 14, 2025Peer-reviewedNeuroscience

Huntingtin lowering reduces somatic instability at CAG-expanded loci

Sydney R. Coffey, Marissa A Andrew, Heather Ging, Joseph Hamilton, Michael D. Flower, Marina V. Kovalenko, Robert M. Bragg, Jeffrey P. Cantle, Cassandra A. McHugh, José M. Carrillo, Julie-Anne Rodier, Deanna M. Marchionini, Hilary A. Wilkinson, Seung Kwak, David Howland, , Jeffrey B. Carroll

This study shows that reducing huntingtin protein levels decreases somatic instability in CAG-expanded loci in both mouse models and human neurons.

bioRxiv · Jul 23, 2020 · PreprintNeuroscience