Heather K. MacAlpine

Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation

The paper uses genetic perturbations and MNase-seq to study chromatin and TF responses in yeast, revealing chromatin-mediated regulatory mechanisms and networks.

Spatiotemporal kinetics of CAF-1-dependent chromatin maturation ensures transcription fidelity during S-phase

This study investigates how CAF-1-dependent chromatin maturation affects transcription fidelity during S-phase in yeast, showing that CAF-1 loss leads to heterogeneous nucleosome assembly and transient gene silencing defects.

Linking the dynamics of chromatin occupancy and transcription with predictive models

The paper develops predictive models linking chromatin dynamics and transcription by analyzing chromatin and RNA data in yeast under cadmium stress.

Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication

The paper investigates how nucleosome dynamics and eviction after a double-strand break are reversible via NHEJ repair in yeast, showing re-establishment of chromatin structure in G1-arrested cells.

Disruption of origin chromatin structure by helicase activation in the absence of DNA replication

The paper studies helicase activation in the absence of DNA replication and finds it disrupts chromatin structure and activates the intra-S-phase checkpoint.

Nascent chromatin occupancy profiling reveals locus and factor specific chromatin maturation dynamics behind the DNA replication fork

The paper develops NCOPs to study chromatin maturation dynamics behind the DNA replication fork and identifies locus-specific differences and factor-specific transient occupancy.