Rachel A. Hoffman

This study identifies PAX3::FOXO1 and MYCN as cooperative regulators of MIR17HG expression in fusion-positive rhabdomyosarcoma and shows miR-17-92 is necessary for oncogenic activity.

This paper compares the chromatin engagement mechanisms of PAX3::FOXO1 and PAX7::FOXO1 fusions in rhabdomyosarcoma using modified MNase ChIP and identifies distinct nucleosome targeting patterns.

This study investigates the role of Myc family proteins in FP-RMS, showing MYCN or MYC dominance in some cases and functional redundancy in others, with both contributing to oncogenic properties.

This study shows that varying levels of PAX3::FOXO1 protein affect cell state and epigenetic heterogeneity in rhabdomyosarcoma.

The paper studies helicase activation in the absence of DNA replication and finds it disrupts chromatin structure and activates the intra-S-phase checkpoint.