UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment by regulating tumour cell fate
Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David MacLean, Nicole Machado, Gonzalo Rodríguez‐Berriguete, Lolita Singh, Geoff Stuart Higgins, Ester M. Hammond, Monica M. Olcina
This study shows hypoxia induces intracellular C5aR1 via UPR, promoting tumour cell survival by regulating autophagy and apoptosis.
Cell Death and Disease · Jul 22, 2025Peer-reviewedCancer Biology