ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer's disease
Aphrodite Demetriou, Birgitta Lindqvist, Heba G. Ali, Mohamed M. Shamekh, Silvia Maioli, José Inzunza, Mukesh Varshney, Per Nilsson, Ivan Nalvarte
This study investigates ERβ's role in sex-specific protection against AD pathology in AppNL-G-F mice, finding ERβ activation protects both males and females, with ovariectomy increasing Aβ levels but limited overall pathology effects.
bioRxiv · Jul 22, 2024 · PreprintNeuroscience