Author

Silvia Maioli

Karolinska InstitutetORCID 0000-0002-9577-0803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 5 Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

Patricia Rodriguez‐RodrigueziD· 4 shared Anna MattoniD· 3 shared Francesca Eroli· 3 shared Julen GoikoleaiD· 3 shared María Latorre‐LealiD· 3 shared Per NilssoniD· 3 shared Vilma AlankoiD· 3 shared Ángel Cedazo-Mı́ngueziD· 2 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Patricia Rodriguez‐RodriguezORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology

Patricia Rodriguez‐Rodriguez, Wei Wang, Christina Tsagkogianni, Irena Feng, Ana Morello-Megias, Kaahini Jain, Vilma Alanko, Han Ali Kahvecioglu, Elyas Mohammadi, Xiaofei Li, Marc Flajolet, Anna Matton, Silvia Maioli, Noemí Vidal, Ana Milosevic, Jean-Pierre Roussarie

This study profiles cell-type specific changes in human entorhinal cortex at early Alzheimer's disease stages, identifying dysregulation of Reelin signaling and downregulation of NPTX2 and CBLN4.

bioRxiv · Dec 31, 2024 · PreprintNeuroscience

Mouse PAW: reverse-translating the FINGER multimodal lifestyle intervention enhances synaptic plasticity and cognition in adult wild type female mice

Vilma Alanko, Francesca Eroli, Ákos Végvári, Alina Solomon, Tobias Hartmann, Per Nilsson, Miia Kivipelto, Silvia Maioli, Anna Matton

This study applies a multimodal lifestyle intervention in mice to improve cognition and synaptic plasticity, showing effects comparable to pharmacological interventions.

bioRxiv · Sep 23, 2024 · PreprintNeuroscience

ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer's disease

Aphrodite Demetriou, Birgitta Lindqvist, Heba G. Ali, Mohamed M. Shamekh, Silvia Maioli, José Inzunza, Mukesh Varshney, Per Nilsson, Ivan Nalvarte

This study investigates ERβ's role in sex-specific protection against AD pathology in AppNL-G-F mice, finding ERβ activation protects both males and females, with ovariectomy increasing Aβ levels but limited overall pathology effects.

bioRxiv · Jul 22, 2024 · PreprintNeuroscience

Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression.

Giusy Pizzirusso, Efthalia Preka, Julen Goikolea, Celia Aguilar-Ruiz, Patricia Rodriguez‐Rodriguez, Guillermo Vazquez Cabrera, Simona Laterza, María Latorre‐Leal, Francesca Eroli, Klas Blomgren, Silvia Maioli, Per Nilsson, Adamantia F. Fragopoulou, André Fisahn, Luis Enrique Arroyo‐García

The paper investigates how microglia loss in the hippocampus contributes to early amyloid pathology progression by disrupting neural oscillations and synaptic function in a mouse model.

bioRxiv · Mar 14, 2024 · PreprintNeuroscience

Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities

Makrina Daniilidou, Francesca Eroli, Vilma Alanko, Julen Goikolea, María Latorre‐Leal, Patricia Rodriguez‐Rodriguez, William James Griffiths, Yuqin Wang, Manuela Pacciarini, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Anna Rosenberg, Nenad Bogdanović, Bengt G. Winblad, , Anna Matton

The paper identifies Alzheimer's disease biomarkers in a cohort without common comorbidities, finding associations between biomarkers and pathways like neuroinflammation and oxidative stress.

Brain Communications · Jan 1, 2023Peer-reviewedNeuroscience

Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia

Julen Goikolea, Jean-Pierre Roussarie, Gorka Gereñu, Raúl Loera‐Valencia, María Latorre‐Leal, Ángel Cedazo-Mı́nguez, Patricia Rodriguez‐Rodriguez, Silvia Maioli

This study identifies Trx80 as a neuron-derived peptide that modulates microglia interferon response via Trem2-dependent mechanisms in Alzheimer's disease models.

bioRxiv · Mar 9, 2022 · PreprintNeuroscience