Single-cell epigenomic dysregulation of Systemic Sclerosis fibroblasts via CREB1/EGR1 axis in self-assembled human skin equivalents
Tamar R. Abel, Noelle N. Kosarek, Rezvan Parvizi, Helen C. Jarnagin, Gretel M. Torres, Rajan Bhandari, Mengqi Huang, Diana M. Toledo, Avi Smith, Dillon Popovich, Michael Mariani, Hee-Taek Yang, Tammara A. Wood, Jonathan A. Garlick, Patricia Ann Pioli, Michael L. Whitfield
The paper characterizes single-cell transcriptomic and epigenomic features of a 3D skin-like model of systemic sclerosis, identifying fibroblast subpopulations and their interactions with macrophages.
bioRxiv · Mar 22, 2024 · PreprintGenomics