Author

Helen Irving

Liverpool School of Tropical Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Ecology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Charles Sinclair WondjiiD· 5 shared Jack HearniD· 4 shared Sulaiman S. IbrahimiD· 4 shared Abdullahi MuhammadiD· 3 shared Gareth D. WeedalliD· 2 shared Leon M. J. MugenziiD· 2 shared Talal Al‐YazeediiD· 2 shared Abdullahi Sabo MuhammadiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersGenomics

Charles Sinclair WondjiORCID

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Author profile →

5 papers

Recent·Most cited

Generational selection, transcriptomics and functional characterization reveal the impact of environmental pollutants on the evolution of insecticide resistance in malaria vectors

Abdullahi Muhammad, Sulaiman S. Ibrahim, Helen Irving, Talal Al‐Yazeedi, Jack Hearn, Mark J. I. Paine, Charles Sinclair Wondji

The paper investigates how environmental pollutants like PAHs affect insecticide resistance in malaria vectors through multi-generational selection experiments and transcriptomic analysis.

Insect Biochemistry and Molecular Biology · Aug 15, 2026Peer-reviewedEcology

A panel of CYP6Z genes drives broad-spectrum cross-resistance to public health insecticides in the major malaria vector An. gambiae s.s.

Mersimine Kouamo, Arnaud Tepa, Abdullahi Sabo Muhammad, Vanessa B. Ngannang-Fezeu, Jonas Arnaud Kengne-Ouafo, Murielle J. Wondji, Helen Irving, Sulaiman S. Ibrahim, Charles Sinclair Wondji

This study identifies CYP6Z genes in An. gambiae as drivers of broad-spectrum insecticide resistance through transcriptional upregulation and functional validation.

bioRxiv · Dec 23, 2025 · PreprintMolecular Biology

Overexpression and nonsynonymous mutations of UDP-glycosyltransferases potentially associated with pyrethroid resistance in Anopheles funestus

Talal Al‐Yazeedi, Abdullahi Muhammad, Helen Irving, Seung‐Joon Ahn, Jack Hearn, Charles Sinclair Wondji

The paper identifies overexpression and nonsynonymous mutations in UGT genes associated with pyrethroid resistance in Anopheles funestus using GWAS-PoolSeq and transcriptomic analysis.

bioRxiv · Aug 25, 2023 · PreprintGenetics

Multi-omics analysis identifies a CYP9K1 haplotype conferring pyrethroid resistance in the malaria vector Anopheles funestus in East Africa

Jack Hearn, Carlos S. D. Tagne, Sulaiman S. Ibrahim, Billy Tene Fossog, Leon M. J. Mugenzi, Helen Irving, Jacob M. Riveron, Gareth D. Weedall, Charles Sinclair Wondji

This study identifies a CYP9K1 haplotype associated with pyrethroid resistance in Anopheles funestus using multi-omics analysis and functional validation.

Molecular Ecology · May 12, 2022Peer-reviewedGenomics

Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii

Sulaiman S. Ibrahim, Abdullahi Muhammad, Jack Hearn, Gareth D. Weedall, Sanjay Curtis Nagi, Muhammad Mahmood Mukhtar, Amen Nakebang Fadel, Leon M. J. Mugenzi, Edward I. Patterson, Helen Irving, Charles Sinclair Wondji

The paper identifies molecular drivers of insecticide resistance in Anopheles coluzzii populations across the Sahel region, highlighting key genes and chromosomal inversions associated with resistance to pyrethroids and other insecticides.

bioRxiv · Mar 21, 2022 · PreprintGenomics