Abdullahi Muhammad

The metabolic resistance blueprint: Genomic dissection of DDT resistance in historical kdr-free East African Anopheles gambiae

This paper identifies genomic loci and mutations associated with DDT metabolic resistance in Anopheles gambiae using bulk segregant analysis and confirms their selection in natural populations.

Generational selection, transcriptomics and functional characterization reveal the impact of environmental pollutants on the evolution of insecticide resistance in malaria vectors

The paper investigates how environmental pollutants like PAHs affect insecticide resistance in malaria vectors through multi-generational selection experiments and transcriptomic analysis.

Transcriptomic profiling reveals multiple mechanisms of insecticide resistance in Aedes aegypti from Angola

This study identifies multiple insecticide resistance mechanisms in Angolan Aedes aegypti using transcriptomic analysis, revealing shared and novel resistance genes compared to other regions.

Genetic mapping of resistance: A QTL and associated polymorphism conferring resistance to alpha-cypermethrin in Anopheles funestus

This study identifies a QTL and associated polymorphisms conferring resistance to alpha-cypermethrin in Anopheles funestus using genetic crosses and BSA mapping.

A single mutation G454A in P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy

This study identifies a single mutation G454A in CYP9K1 as a driver of pyrethroid resistance in Anopheles funestus, reducing bed net efficacy and highlighting the need for resistance monitoring.

Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b drive pyrethroid resistance in Anopheles funestus

This study identifies two mutations in CYP6P4a and CYP6P4b genes driving pyrethroid resistance in Anopheles funestus and develops DNA-based assays to detect these mutations in West Africa.

A single E205D allele of a key P450 CYP6P3 is driving metabolic pyrethroid resistance in the major African malaria vector Anopheles gambiae

This study identifies the E205D mutation in CYP6P3 as a driver of pyrethroid resistance in Anopheles gambiae, showing its association with resistance and its interaction with kdr mutations.

Overexpression and nonsynonymous mutations of UDP-glycosyltransferases potentially associated with pyrethroid resistance in Anopheles funestus

The paper identifies overexpression and nonsynonymous mutations in UGT genes associated with pyrethroid resistance in Anopheles funestus using GWAS-PoolSeq and transcriptomic analysis.

Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii

The paper identifies molecular drivers of insecticide resistance in Anopheles coluzzii populations across the Sahel region, highlighting key genes and chromosomal inversions associated with resistance to pyrethroids and other insecticides.