Sulaiman S. Ibrahim

Generational selection, transcriptomics and functional characterization reveal the impact of environmental pollutants on the evolution of insecticide resistance in malaria vectors

The paper investigates how environmental pollutants like PAHs affect insecticide resistance in malaria vectors through multi-generational selection experiments and transcriptomic analysis.

Metabolomic changes underpinning permethrin resistance in the Anopheles gambiae malaria vector from Cameroon

This study identifies metabolomic changes in permethrin-resistant Anopheles gambiae mosquitoes from Cameroon, revealing metabolic and detoxification pathways contributing to resistance.

A panel of CYP6Z genes drives broad-spectrum cross-resistance to public health insecticides in the major malaria vector An. gambiae s.s.

This study identifies CYP6Z genes in An. gambiae as drivers of broad-spectrum insecticide resistance through transcriptional upregulation and functional validation.

A single mutation G454A in P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy

This study identifies a single mutation G454A in CYP9K1 as a driver of pyrethroid resistance in Anopheles funestus, reducing bed net efficacy and highlighting the need for resistance monitoring.

Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b drive pyrethroid resistance in Anopheles funestus

This study identifies two mutations in CYP6P4a and CYP6P4b genes driving pyrethroid resistance in Anopheles funestus and develops DNA-based assays to detect these mutations in West Africa.

A single E205D allele of a key P450 CYP6P3 is driving metabolic pyrethroid resistance in the major African malaria vector Anopheles gambiae

This study identifies the E205D mutation in CYP6P3 as a driver of pyrethroid resistance in Anopheles gambiae, showing its association with resistance and its interaction with kdr mutations.

Multi-omics analysis identifies a CYP9K1 haplotype conferring pyrethroid resistance in the malaria vector Anopheles funestus in East Africa

This study identifies a CYP9K1 haplotype associated with pyrethroid resistance in Anopheles funestus using multi-omics analysis and functional validation.

Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii

The paper identifies molecular drivers of insecticide resistance in Anopheles coluzzii populations across the Sahel region, highlighting key genes and chromosomal inversions associated with resistance to pyrethroids and other insecticides.