The Nanog epigenetic remodeling complex was essential to vertebrate mesoderm evolution
Luke A. Simpson, Darren Crowley, Teri Forey, Helena Acosta, Zoltán Ferjentsik, Jodie Chatfield, Alexander Payne, Benjamin Scott S Simpson, Catherine Redwood, James E. Dixon, Nadine Holmes, Fei Sang, Ramiro Alberio, Matthew Loose, Andrew D. Johnson
The paper shows that NANOG and NODAL interact with DPY30 to regulate H3K4me3 deposition in axolotl primitive ectoderm, conserved in humans, establishing a basal state of vertebrate pluripotency.
bioRxiv · Sep 8, 2022 · PreprintDevelopmental Biology