Fei Sang

OpenSplice quantifies the impact of over 590,000 variants on the splicing of 600 human exons, providing insights into splicing regulatory mechanisms and enabling machine learning model evaluation.

This study shows that paternal over- and under-nutrition affects fetal and placental development in a sex-specific manner in mice, without significantly impacting male fertility.

This study creates a single-cell transcriptomic atlas of pig gastrulation, revealing conserved and divergent gene programs and fate dynamics across species.

The paper shows that NANOG and NODAL interact with DPY30 to regulate H3K4me3 deposition in axolotl primitive ectoderm, conserved in humans, establishing a basal state of vertebrate pluripotency.

This study investigates epigenetic reprogramming in pig primordial germ cells, identifying similarities with human germline processes and potential for transgenerational epigenetic inheritance.

The paper analyzes pig embryos at single-cell resolution to study lineage segregation, pluripotency, and X-chromosome inactivation during early development, revealing conserved mechanisms with human embryos.