The Nanog epigenetic remodeling complex was essential to vertebrate mesoderm evolution
Luke A. Simpson, Darren Crowley, Teri Forey…·Andrew D. Johnson
The paper shows that NANOG and NODAL interact with DPY30 to regulate H3K4me3 deposition in axolotl primitive ectoderm, conserved in humans, establishing a basal state of vertebrate pluripotency.