Nadine Holmes

This study shows that paternal over- and under-nutrition affects fetal and placental development in a sex-specific manner in mice, without significantly impacting male fertility.

FindingNemo improves ultra-long nanopore sequencing by optimizing DNA extraction and library preparation for higher yields and scalability.

This study creates a single-cell transcriptomic atlas of pig gastrulation, revealing conserved and divergent gene programs and fate dynamics across species.

The paper shows that NANOG and NODAL interact with DPY30 to regulate H3K4me3 deposition in axolotl primitive ectoderm, conserved in humans, establishing a basal state of vertebrate pluripotency.

This study shows that genetic variation in rDNA affects epigenetic states and rRNA expression in mice and humans, with species-specific patterns observed.

The paper introduces a barcode-aware adaptive sampling tool for nanopore sequencers, enabling targeted analysis of multiple genomes on a single flow cell.

MinoTour provides a LIMS system for real-time monitoring and analysis of Oxford Nanopore sequencers, enabling automated analysis during sequencing runs.

The paper demonstrates how real-time nanopore sequencing with minoTour can accelerate SARS-CoV-2 consensus generation and lineage assignment by predicting optimal sequencing completion points.

The paper introduces a method for targeted sequencing using nanopore adaptive sequencing, enabling efficient enrichment of specific genes and chromosomes from mixed samples.

The paper presents a gapless, telomere-to-telomere assembly of the human X chromosome using ultra-long-read nanopore sequencing and complementary technologies.

The paper uses nanopore sequencing to analyze poly(A) RNA from human cells, identifying long transcripts and modifications not captured by traditional methods.

BulkVis visualizes Oxford Nanopore bulk fast5 files to inspect signal data and identify incorrectly split long reads.