Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation
Qiangqiang Zhang, Guohua Yuan, Elena Albizzati, Jiajun Yang, Zhe Zhao, Xiaojuan Yu, Xuyao Chang, Choong H. Lee, Heng Du, Zhimin Lao, Anjana Krishnamurthy, XP Zhang, Xiaohui Lv, Xing Tang, Shuhan Hu, , Song‐Hai Shi
This study shows that NFI proteins regulate radial glial progenitor lifespan and output in a dose-dependent manner, affecting neocortical development and causing malformations in human cerebral organoids and mouse models.
bioRxiv · Dec 27, 2025 · PreprintNeuroscience