Zhimin Lao

This study shows that NFI proteins regulate radial glial progenitor lifespan and output in a dose-dependent manner, affecting neocortical development and causing malformations in human cerebral organoids and mouse models.

This study identifies SP5 and SP8 as transcription factors that drive primary cilia formation through genetic and transcriptomic analyses in mouse embryos.

This study shows that PTEN loss accelerates SHH medulloblastoma growth through both cell-autonomous and nonautonomous mechanisms in mouse models.

This study shows that ablating cerebellar output neurons has less impact on behavior than genetic mutations in these neurons, which cause additional deficits in learning and memory.

The paper identifies molecular subdomains in the medial excitatory cerebellar nucleus (eCNm) and shows that En1/2 mutations disrupt their development and survival.

The paper identifies a transitory cell state driven by ASCL1 that enables neural reprogramming in the injured neonatal brain.

The paper shows that reduction of cerebellar nuclei neurons leads to proportional scaling down of cerebellar cortex growth due to loss of their presynaptic Purkinje cells.