Song‐Hai Shi

Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation

This study shows that NFI proteins regulate radial glial progenitor lifespan and output in a dose-dependent manner, affecting neocortical development and causing malformations in human cerebral organoids and mouse models.

Neocortical temporal patterning by a two-layered regulatory network

The paper identifies a two-layered regulatory network governing temporal patterning in neocortical development through single-cell multi-omics analysis.

Cortex Folding by Combined Progenitor Expansion and Adhesion-Controlled Neuronal Migration

The paper shows that combining progenitor expansion with adhesion-controlled neuronal migration enhances cortex folding in mice, leading to sulci and gyri formation.

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

AQuA2 quantifies molecular spatiotemporal signals from live imaging data by decomposing complex datasets into signaling events, demonstrating applications across biosensors and cell types.

A Silicon Diode based Optoelectronic Interface for Bidirectional Neural Modulation

This paper demonstrates a silicon diode device that bidirectionally modulates neural activity in vitro and in vivo through photothermal and photovoltaic effects.

Distinct progenitor behavior underlying neocortical gliogenesis related to tumorigenesis

The paper quantifies the progenitor cell behavior and gliogenesis program in the mouse neocortex, revealing a 60%:15%:25% propensity for astrocytes, oligodendrocytes, and both, and links gliogenesis to tumor suppressor loss.

Adult newborn granule cells confer emotional-state-dependent plasticity in memory retrieval

The paper shows adult newborn granule cells mediate emotional-state-dependent plasticity in memory retrieval, with social reward enhancing and stress weakening memory reactivation.