Anjana Krishnamurthy

Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation

This study shows that NFI proteins regulate radial glial progenitor lifespan and output in a dose-dependent manner, affecting neocortical development and causing malformations in human cerebral organoids and mouse models.

Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity

This study shows that ablating cerebellar output neurons has less impact on behavior than genetic mutations in these neurons, which cause additional deficits in learning and memory.

Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival

The paper identifies molecular subdomains in the medial excitatory cerebellar nucleus (eCNm) and shows that En1/2 mutations disrupt their development and survival.