Heng Kang Yao

This study links reduced PV and SST interneuron inhibition in schizophrenia to distinct EEG biomarkers using in silico simulations of prefrontal microcircuits.

The paper tests methods for deriving connectivity from spiking activity in detailed cortical microcircuits and finds that activation paradigms significantly affect derivation accuracy.

This study shows that spine loss in depression impairs dendritic signal integration in human cortical microcircuits, leading to greater functional impairment than reduced inhibition alone.

The paper models human cortical microcircuits to show reduced inhibition in depression impairs stimulus processing by increasing baseline activity and reducing signal-to-noise ratio.