Homeira Moradi Chameh

Laser-integrated nanophotonic neural probes with on-chip sensors for addressable photostimulation

This paper develops laser-integrated nanophotonic neural probes with on-chip sensors for scalable photostimulation and feedback monitoring in optogenetic experiments.

Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy

This study identifies somatic Ras-MAPK pathway variants in hippocampal tissue from patients with drug-resistant epilepsy, showing their association with clonal competition and worse surgical outcomes.

Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery

This paper introduces multifunctional nanophotonic neural probes that combine photostimulation, electrophysiology, and microfluidic delivery for in vivo use in mice.

Hyperpolarization-activated cation channel mediated intrinsic plasticity changes underlie the malleability of with-in cell-type electrophysiological heterogeneity

The paper shows that within-cell-type electrophysiological heterogeneity is malleable and can be restored by blocking HCN currents in epilepsy models.

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression

The paper models the effects of 5-PAM on human cortical microcircuits to assess its potential in treating depression and identifies EEG biomarkers for drug efficacy.

Hyperpolarization-activated cation channels shape the spiking frequency preference of human cortical layer 5 pyramidal neurons

The paper investigates the role of hyperpolarization-activated currents in shaping spiking frequency preference of human cortical layer 5 neurons using computational models and experimental validation.

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

The paper identifies age-related increases in sag voltage amplitude in human pyramidal neurons and shows reduced baseline firing in older neuron microcircuits.

Resilience through diversity: Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony

The paper shows that reduced neuronal heterogeneity in epileptogenic tissue decreases network resilience to synchrony changes, leading to seizure-like dynamics.

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

The paper models human cortical microcircuits to show reduced inhibition in depression impairs stimulus processing by increasing baseline activity and reducing signal-to-noise ratio.

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

The paper characterizes electrophysiological diversity among human cortical pyramidal neurons by analyzing sag currents and frequency preferences across different cortical layers.

Modeling reveals human-rodent differences in h-current kinetics influencing resonance in cortical layer 5 neurons

The paper develops a biophysically detailed human layer 5 cortical neuron model showing slower h-current kinetics compared to rodents, leading to differences in resonance and post-inhibitory rebound.

Modeling implicates inhibitory network bistability as an underpinning of seizure initiation

The paper uses computational models to show that hyper-excitable inhibitory networks can transition from asynchronous to synchronous activity, potentially explaining seizure initiation.