Alexandre Guet-McCreight

Preserving spiking and EEG in detailed models of human cortical microcircuits with morphological reductions

This study evaluates morphological reduction and synapse merging methods to speed up cortical microcircuit simulations while preserving spiking and EEG accuracy.

Median raphe input to dorsal CA1 shapes VIP interneuron recruitment and novelty-guided spatial memory

The paper identifies median raphe projections as a pathway that modulates VIP interneuron recruitment and spatial memory during novel experiences.

Linking age changes in human cortical microcircuits to impaired brain function and EEG biomarkers

The paper links age-related cellular and synaptic changes in human cortical microcircuits to impaired brain function and EEG biomarkers using computational models and machine learning.

Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits

The paper tests methods for deriving connectivity from spiking activity in detailed cortical microcircuits and finds that activation paradigms significantly affect derivation accuracy.

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity

This study predicts optimal 5-PAM doses for depression treatment using simulated EEG data and machine learning models.

EEG biomarkers of α5-GABA positive allosteric modulators in rodents

This study identifies distinct EEG biomarkers for 5-PAM in rodents, showing specific changes in theta and beta/gamma power compared to diazepam.

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression

The paper models the effects of 5-PAM on human cortical microcircuits to assess its potential in treating depression and identifies EEG biomarkers for drug efficacy.

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

The paper identifies age-related increases in sag voltage amplitude in human pyramidal neurons and shows reduced baseline firing in older neuron microcircuits.

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

The paper models human cortical microcircuits to show reduced inhibition in depression impairs stimulus processing by increasing baseline activity and reducing signal-to-noise ratio.

Deciphering how interneuron specific 3 cells control oriens lacunosum-moleculare cells to contribute to circuit function

The paper uses computational modeling to show how I-S3 interneurons suppress OLM cell spiking and contribute to theta frequency resonance in simulated scenarios.

Somatodendritic HCN channels in hippocampal OLM cells revealed by a convergence of computational models and experiments

The paper integrates computational models and experiments to show that hippocampal OLM cells have dendritic HCN2 channels, supporting theta spiking resonance.

Synaptic mechanisms underlying the network state-dependent recruitment of VIP-expressing interneuron-specific interneurons in the CA1 hippocampus

The paper identifies synaptic mechanisms controlling VIP-expressing interneurons' firing and their recruitment during theta oscillations and ripples in the hippocampus.

Weak and equally balanced synaptic inputs to interneurons in the CA1 hippocampus characterize in vivo rhythmic states

The paper uses computational models to predict balanced synaptic states in hippocampal circuits during rhythmic activities.