CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma
Kathleen M. McAndrews, Krishnan K. Mahadevan, Bingrui Li, Amari M. Sockwell, Sami J. Morse, Patience J. Kelly, Sarah I. Patel, Michelle L. Kirtley, Barbara A. Moreno Diaz, Hengyu Lyu, David H. Peng, Xunian Zhou, Hikaru Sugimoto, Aaron A. Bickert, Lakshmi Kavitha Sthanam, , Raghu Kalluri
This study investigates how CDK8 remodels the tumor microenvironment to resist KRASG12D inhibition in PDAC, showing that targeting CDK8 can overcome resistance and improve survival.
bioRxiv · Jan 29, 2025 · PreprintCancer Biology