Author

Hikaru Sugimoto

The University of Texas MD Anderson Cancer CenterORCID 0000-0003-0499-3962Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Developmental Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Raghu KalluriiD· 5 shared Kent A. Arian· 3 shared Krishnan K. MahadevaniD· 3 shared Sami J. MorseiD· 3 shared Shreyasee V. Kumbhar· 3 shared Aaron A. Bickert· 2 shared Amari M. SockwelliD· 2 shared Anirban MaitraiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersCancer Biology

Raghu KalluriORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 11, 2026

Engineered extracellular vesicles targeting BACE1 reduces amyloid beta plaque formation in a genetic mouse model of Alzheimer Disease

Valerie S. Kalluri, Sara P.Y. Che, Meagan Conner…·Raghu Kalluri

This study shows engineered extracellular vesicles delivering BACE1-targeting siRNA reduce amyloid beta plaques in a mouse model of Alzheimer's disease.

DOI 10.64898/2026.08.10.744066

mouseproteomics

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Cancer BiologybioRxivPreprintFeb 28, 2025

Distinct small molecule inhibitors of Kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancer

Krishnan K. Mahadevan, Ana S. Maldonado, Bingrui Li…·Raghu Kalluri

This study identifies small molecule Kras inhibitors that synergize with anti-CTLA4 therapy to reprogram Tregs and enhance immunotherapy efficacy in PDAC.

7 citations

humanATAC-seq

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Cancer BiologybioRxivPreprintJan 29, 2025

CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma

Kathleen M. McAndrews, Krishnan K. Mahadevan, Bingrui Li…·Raghu Kalluri

This study investigates how CDK8 remodels the tumor microenvironment to resist KRASG12D inhibition in PDAC, showing that targeting CDK8 can overcome resistance and improve survival.

4 citations

humanspatial transcriptomics

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ImmunologyJournal of Controlled ReleasePeer-reviewedAug 30, 2024

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

Xin Luo, Kathleen M. McAndrews, Kent A. Arian…·Raghu Kalluri

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

30 citations

mousenon-human primate

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Developmental BiologyDevelopmental DynamicsPeer-reviewedApr 1, 2023

Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish

Valerie S. LeBleu, Jianli Dai, Susan E. Tsutakawa…·Raghu Kalluri

The paper identifies structural differences in zebrafish α4 chain of type IV collagen and shows its conserved anti-angiogenic activity compared to humans.

3 citations

zebrafishprotein sequence

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