Author

Xunian Zhou

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-3287-8913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Bingrui LiiD· 2 shared Kent A. Arian· 2 shared Michelle L. KirtleyiD· 2 shared Raghu KalluriiD· 2 shared Aaron A. Bickert· 1 shared Alondra N. Camacho-Acevedo· 1 shared Amari M. SockwelliD· 1 shared Anaïs M Comptdaer· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCell Biology

Bingrui LiORCID

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2 papers

Recent·Most cited

TGF-β2-induced Snail-mediated EndMT signaling relies on both Smad-dependent and independent pathways

Valerie S. LeBleu, Bingrui Li, Anaïs M Comptdaer, Michelle L. Kirtley, Kent A. Arian, Xunian Zhou, Raghu Kalluri

The paper reproduces and validates a previously reported model of TGF-β2-induced EndMT through Smad-dependent and independent pathways across multiple studies and laboratories.

bioRxiv · Aug 20, 2026 · PreprintCell Biology

CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma

Kathleen M. McAndrews, Krishnan K. Mahadevan, Bingrui Li, Amari M. Sockwell, Sami J. Morse, Patience J. Kelly, Sarah I. Patel, Michelle L. Kirtley, Barbara A. Moreno Diaz, Hengyu Lyu, David H. Peng, Xunian Zhou, Hikaru Sugimoto, Aaron A. Bickert, Lakshmi Kavitha Sthanam, , Raghu Kalluri

This study investigates how CDK8 remodels the tumor microenvironment to resist KRASG12D inhibition in PDAC, showing that targeting CDK8 can overcome resistance and improve survival.

bioRxiv · Jan 29, 2025 · PreprintCancer Biology