Computer Designed PRC2 Inhibitor, EBdCas9, Reveals Functional TATA boxes in Distal Promoter Regions
Shiri Levy, Logeshwaran Somasundaram, Infencia Xavier Raj, Diego Ic-Mex, Sven Schmidt, Ammar Alghadeer, Henrik Honkanen, R. David Hawkins, Julie Mathieu, Yuliang Wang, David A. Baker, Karol Bomsztyk, Hannele Ruohola‐Baker
The paper uses a computationally designed PRC2 inhibitor, EBdCas9, to identify functional TATA boxes in distal promoter regions and demonstrate their role in gene activation.
bioRxiv · Nov 16, 2020 · PreprintMolecular Biology