R. David Hawkins

Computer Designed PRC2 Inhibitor, EBdCas9, Reveals Functional TATA boxes in Distal Promoter Regions

The paper uses a computationally designed PRC2 inhibitor, EBdCas9, to identify functional TATA boxes in distal promoter regions and demonstrate their role in gene activation.

An atlas of silencer elements for the human and mouse genomes

The paper identifies and characterizes silencer elements genome-wide in human and mouse genomes using computational methods and experimental validation.

Single-cell analysis of Non-CpG methylation dynamics and gene expression in human oocyte maturation

The paper investigates non-CpG methylation dynamics and gene expression in human oocyte maturation, finding that non-CG DMRs correlate with gene expression changes and transcription factor binding.

DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory organ of Corti

The paper analyzes DNA methylation dynamics in the mouse auditory organ of Corti during development and maturation, identifying novel regulatory regions and candidate factors involved in inner ear development.

Epigenomic and 3D genome architecture in naïve and primed human embryonic stem cell states

The paper compares epigenomic and 3D genome architecture between naive and primed human embryonic stem cells, showing differences in enhancer marking and chromatin domain organization.