Author

Infencia Xavier Raj

Washington University in St. LouisORCID 0000-0002-4889-4643Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Aishwarya KrishnaniD· 3 shared Grant Anthony ChalleniD· 3 shared Jason Arand· 3 shared Andrew L. YoungiD· 2 shared Hassan BjeijeiD· 2 shared Jeffrey A. MageeiD· 2 shared Nancy Issa· 2 shared Tyler M. ParsonsiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Aishwarya KrishnanORCID

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Author profile →

4 papers

Recent·Most cited

JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation

Wentao Han, Hassan Bjeije, Hamza Celik, Michael P. Rettig, Nancy Issa, Andrew L. Young, Yanan Li, Infencia Xavier Raj, Christine R. Zhang, Aishwarya Krishnan, Tyler M. Parsons, Samantha C. Burkart, Jason Arand, Wei Yang, Jeffrey A. Magee, Grant Anthony Challen

JARID2 inhibition enhances repopulating activity of human hematopoietic stem and progenitor cells in vivo via STAT1 upregulation.

Blood Advances · Jul 23, 2026Peer-reviewedDevelopmental Biology

JAK2V617F Myeloproliferative Neoplasms Support Parallel Evolution of Independent Leukemic Clones

Tyler M. Parsons, Aishwarya Krishnan, Infencia Xavier Raj, Andrew L. Young, David R O’Leary, Jason Arand, Maggie Cox, Stephen T. Oh, Grant Anthony Challen

This study shows that leukemic clones can evolve independently of JAK2V617F in MPNs and contribute to disease progression through pro-inflammatory environments.

bioRxiv · Sep 23, 2025 · PreprintCancer Biology

Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment

Hassan Bjeije, Wentao Han, Nancy Issa, Aishwarya Krishnan, Infencia Xavier Raj, Jason Arand, Yanan Li, Wei Yang, Jeffrey A. Magee, Grant Anthony Challen

The paper compares the roles of Jarid2 and Ezh2 in hematopoiesis, finding Jarid2 has PRC2-independent functions affecting lineage commitment.

bioRxiv · Jul 18, 2025 · PreprintGenetics

Computer Designed PRC2 Inhibitor, EBdCas9, Reveals Functional TATA boxes in Distal Promoter Regions

Shiri Levy, Logeshwaran Somasundaram, Infencia Xavier Raj, Diego Ic-Mex, Sven Schmidt, Ammar Alghadeer, Henrik Honkanen, R. David Hawkins, Julie Mathieu, Yuliang Wang, David A. Baker, Karol Bomsztyk, Hannele Ruohola‐Baker

The paper uses a computationally designed PRC2 inhibitor, EBdCas9, to identify functional TATA boxes in distal promoter regions and demonstrate their role in gene activation.

bioRxiv · Nov 16, 2020 · PreprintMolecular Biology