GenomicsNAR Genomics and BioinformaticsPeer-reviewed
A theoretical and experimental framework enables low-coverage sequencing for accurate quantification of genome-wide cytosine modification levels
Christian E. Loo, Johanna M. Fowler, Heqiao Zhu…·Rahul M. Kohli
The paper develops and validates Sparse-Seq, a low-coverage sequencing method for accurate quantification of 5mC and 5hmC levels, showing it is more accessible and less variable than mass spectrometry.
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