Saturated lipid stress attenuates mitochondrial genome synthesis in human cells
Casadora Boone, Sophie Judge, Ahmad Shami, Bezawit T. Danna, Andréa B Ball, Tejashree Pradip Waingankar, Hera Saqub, Ajit S. Divakaruni, Samantha C. Lewis
The paper shows that saturated lipid stress reduces mtDNA synthesis in human cells by disrupting ER-mitochondria contact sites and fatty acid trafficking, which is reversed by monounsaturated fatty acids.
bioRxiv · Jul 28, 2025 · PreprintCell Biology