Andréa B Ball

This study shows Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling by providing a weak TLR4 signal.

The paper shows that saturated lipid stress reduces mtDNA synthesis in human cells by disrupting ER-mitochondria contact sites and fatty acid trafficking, which is reversed by monounsaturated fatty acids.

This study shows that reduced oxidative phosphorylation is not required for pro-inflammatory macrophage activation, challenging the conventional model of mitochondrial reprogramming.