Tejashree Pradip Waingankar

Uncovering moonlighting role of mitochondrial presequence translocase machinery in SOD1-mediated ALS pathogenesis

This study identifies a novel interaction between mutant SOD1 and the TIM23 complex in yeast, revealing its role in mitochondrial dysfunction and ALS pathogenesis.

Self-renewal of neuronal mitochondria through asymmetric division

The paper identifies a mechanism of mitochondrial self-renewal in sensory neurons through asymmetric division, showing mtDNA-rich mitochondria at axon branch points produce mtDNA-depleted daughters.

Saturated lipid stress attenuates mitochondrial genome synthesis in human cells

The paper shows that saturated lipid stress reduces mtDNA synthesis in human cells by disrupting ER-mitochondria contact sites and fatty acid trafficking, which is reversed by monounsaturated fatty acids.

A spatial atlas of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress

This study reveals spatial organization of mitochondrial RNA translation and remodeling under stress in human cells.