Cell BiologybioRxivPreprint
Saturated lipid stress attenuates mitochondrial genome synthesis in human cells
Casadora Boone, Sophie Judge, Ahmad Shami…·Samantha C. Lewis
The paper shows that saturated lipid stress reduces mtDNA synthesis in human cells by disrupting ER-mitochondria contact sites and fatty acid trafficking, which is reversed by monounsaturated fatty acids.
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