Mitigation of TDP-43-induced toxic phenotype by expression of RGNEF N-terminal fragment in ALS models
Cristian A. Droppelmann, Danae Campos‐Melo, Verónica Noches, Crystal McLellan, Robert Szabla, Taylor A. Lyons, Hind Amzil, Benjamin Withers, Kirti Shila Sonkar, Anne F. Simon, Emanuele Buratti, Murray S. Junop, Jamie M. Kramer, Michael Joseph Strong
This study shows that expressing a RGNEF N-terminal fragment mitigates TDP-43 toxicity in ALS models by reducing aggregation and neurodegeneration.
bioRxiv · Sep 29, 2023 · PreprintNeuroscience