Modulation of translational elongation by montanine alkaloids preferentially inhibits RNA viruses
RYUICHI SAKAI, Kyohei Sato, Atsushi Tsugita, Lakkana Thaveepornkul, Ayato Takada, Hiroko Miyamoto, Rumi Kurokawa, Minoru W. Yoshida, Takeshi Yokoyama, Antonio Evidente, Yuichiro Tsuge, Hiromi Watari, Tomonosuke Sumiya, Ken Matsumoto, Sarin Chimnaronk, Yoshikazu Tanaka
This study identifies montanine as a potent antiviral compound that inhibits RNA viruses by targeting translational elongation and GCN1-related stress responses.
bioRxiv · Dec 20, 2025 · PreprintBiochemistry