Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer's disease synapse model
Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahashi
The paper shows that soluble wild-type tau in presynaptic terminals causes microtubule assembly, which sequesters dynamin and impairs vesicle endocytosis and neurotransmission in an Alzheimer's disease model.
eLife · Apr 26, 2022Peer-reviewedNeuroscience